Not really.
Nexus, game I liked very much, had fairly generic setting in so far that it had many themes and concepts covered many, many, many times in the literature or games that came before it.
You could just as easily say that Expanse is inspired by the game Terminus from 2000.
Anyway from wiki:
The authors have stated that the series gets some of its inspirations from Fred Pohl's Gateway and the other Heechee books. It has also been observed that there are similarities in the political and social setting of the series to Alfred Bester's classic science fiction novel The Stars My Destination. Ty Franck has also stated Ridley Scott's Alien as having "the single largest influence on The Expanse."